Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Joint Authors
Peng, Weijun
Xu, Panpan
Mao, Dan
Huang, Siqi
Zhang, Shaofan
Zhang, Sifang
Yi, PengJi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
To systematically review whether the Kangai injection (KAI), which is commonly used traditional Chinese medicine, can improve the clinical efficacy of chemotherapy and relieve adverse reactions of chemotherapy in advanced colorectal cancer (CRC) patients.
Methods.
A comprehensive literature search was performed in three English and three Chinese electronic databases until March 2019.
The literature was screened by EndNote X8 and data were analysed by RevMan5 and Stata12.0.
Results.
This meta-analysis consisted of twenty-eight studies, of which 2310 cases were reported.
Among the 2310 cases, 1207 cases were treated with KAI combined with chemotherapy and 1103 cases were treated with chemotherapy alone.
The results showed that KAI combined with chemotherapy significantly improved tumor response (Risk Ratio (RR) =1.32; 95% confidence interval (CI): 1.22-1.43; p<0.00001); Karnofsky performance status (KPS score) (Risk Ratio (RR) =1.48; 95% CI: 1.36-1.60; p<0.00001); reduced adverse drug reactions (ADRs) such as nausea and vomiting (OR =0.31; 95% CI: 0.24-0.41; p <0.00001), diarrhea (OR =0.36; 95% CI: 0.25-0.52; p<0.00001), leukopenia (OR =2.97; 95% CI:2.27-3.88; p<0.00001), thrombocytopenia (OR =0.53; 95% CI: 0.38-0.74; p<0.0002), liver dysfunction (OR =0.29; 95% CI: 0.20-0.44; p<0.00001), neurotoxicity (OR =0.51; 95% CI: 0.36-0.71; p = 0.0004); increased immune function (CD3+: MD=6.34; 95% CI: 5.52-7.16; p < 0.00001, CD4+: MD=-5.99; 95% CI: 5.20-6.78; p < 0.00001; and CD4+/CD8+: MD=0.34; 95% CI: 0.14-0.54; p < 0.0009), and prolonged survival time (OR =1.77; 95% CI: 1.25-2.50; p = 0.001).
Renal dysfunction caused by chemotherapy was not affected by KAI treatment (Odds Ratio (OR) =0.53; 95%IC: 0.25-1.12; p = 0.10).
Conclusion.
KAI can increase clinical effectiveness, improve quality of life, alleviate ADRs, and prolong survival time in advanced colorectal (CRC) patients receiving chemotherapy.
American Psychological Association (APA)
Huang, Siqi& Peng, Weijun& Mao, Dan& Zhang, Shaofan& Xu, Panpan& Yi, PengJi…[et al.]. 2019. Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151268
Modern Language Association (MLA)
Huang, Siqi…[et al.]. Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1151268
American Medical Association (AMA)
Huang, Siqi& Peng, Weijun& Mao, Dan& Zhang, Shaofan& Xu, Panpan& Yi, PengJi…[et al.]. Kangai Injection, a Traditional Chinese Medicine, Improves Efficacy and Reduces Toxicity of Chemotherapy in Advanced Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151268