Dynamic Consistent NSFD Scheme for a Delayed Viral Infection Model with Immune Response and Nonlinear Incidence

Abstract EN

In this paper, a discrete-time model has been proposed by applying nonstandard finite difference (NSFD) scheme to solve a delayed viral infection model with immune response and general nonlinear incidence.

It is shown that the discrete model has equilibria which are exactly the same as those of the original continuous model.

Using discrete-time analogue of Lyapunov functionals, the global asymptotic stability of the equilibria of the discrete model is fully determined by the basic reproduction number of the virus and immune response, R0 and R1, with no restriction on the time step size, which implies that the NSFD scheme preserves the qualitative dynamics of the corresponding continuous model.