Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone
Joint Authors
Al Asoom, Lubna Ibrahim
Al-Hariri, Mohammad Taha
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Back Ground.
Long-term administration of Nigella sativa showed cardiac hypertrophic and positive inotropic effects.
Thymoquinone (TQ) is an active ingredient in Nigella sativa.
Therefore, we aimed to test the cardiac effects of long-term TQ administration.
Materials and Methods.
Twenty adult Wistar rats weighing (150-250 g) were divided into two groups: control and TQ.
A TQ-olive oil solution was administered orally to the TQ group (dose 10 mg/kg) for two months.
An equivalent volume of olive oil was given to the control group.
Langendorff isolated hearts were studied.
Peak tension, time to peak tension, half relaxation time, and myocardial flow rate were determined.
Heart and left ventricle weights and ratios were recorded.
Results.
The TQ group exhibited significantly higher peak tension than the control group.
There were no significant differences between the two groups in time to peak tension, half relaxation time, and myocardial flow rate.
Likewise, there were no signs of cardiac hypertrophy.
Conclusions.
Long-term administration of oral TQ induced a positive inotropic effect in the form of an increase in peak tension.
TQ administration did not result in cardiac hypertrophy or an increased cardiac metabolic demand at the studied dose.
TQ may be a promising inotropic agent.
American Psychological Association (APA)
Al Asoom, Lubna Ibrahim& Al-Hariri, Mohammad Taha. 2019. Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151351
Modern Language Association (MLA)
Al Asoom, Lubna Ibrahim& Al-Hariri, Mohammad Taha. Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1151351
American Medical Association (AMA)
Al Asoom, Lubna Ibrahim& Al-Hariri, Mohammad Taha. Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151351