Nymphaea lotus Linn. (Nymphaeaceae) Alleviates Sexual Disability in L-NAME Hypertensive Male Rats
Joint Authors
Kamtchouing, Pierre
Dimo, Théophile
Bilanda, Danielle Claude
Djomeni Dzeufiet, Paul Désiré
Kameni, Poumeni Mireille
Mballa, Marguerite Francine
Mengue, Ngadena Yolande Sandrine
Tchoupou, Tchinda Huguette
Ouafo, Agnes Carolle
Ngoungoure, Madeleine Chantal
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hypertension (HT) is a risk factor for erectile dysfunction (ED).
This study aimed to evaluate the suppressive effect of Nymphaea lotus (N.
lotus) on erectile dysfunction induced by NO deficiency in rat.
40 male rats equally divided into 4 groups received an oral treatment with 10 mg/kg/day of L-NAME, a NO blocker, during 4 weeks.
Control group composed of 10 male rats received only distilled water (10 mL/kg).
Thereafter oral treatments with N.
lotus (75 and 200 mg/kg/day) and losartan (10 mg/kg/day) started and continued concomitantly with L-NAME in 3 groups for 4 additional weeks.
Normal and negative controls received only distilled water.
Sexual behaviour, orientation activities, anxiety, and penile histomorphology were evaluated at the end of treatment.
L-NAME administration elevated significantly the blood pressure in male rats and decreased the copulatory rate by enhancing intromission latency and decreasing the numbers of intromission and ejaculation.
However, the sexual motivation remains unaltered by chronic NO blockage suggesting that L-NAME induces penile dysfunction mainly by peripheral mechanisms.
L-NAME chronic intake also induced anxiety, 4 weeks of N.
lotus cotreatment prevented inhibitory effects of L-NAME on male sexual behaviour by shortening mainly ejaculation latency and postejaculatory interval while losartan does not.
Losartan proved to be a more effective drug to decrease the blood pressure compared to the plant extract.
Effectively, Nymphea lotus was able to reverse totally at 75 mg/kg the increment of hemodynamic parameters and the histological damage and exhibit anxiolytic-like effects in hypertensive male rats.
Nymphaea lotus uses NO pathway to facilitate sexual responses at central and peripheral levels and can have a double medicinal use, against anxiety and erectile dysfunction.
American Psychological Association (APA)
Kameni, Poumeni Mireille& Djomeni Dzeufiet, Paul Désiré& Bilanda, Danielle Claude& Mballa, Marguerite Francine& Mengue, Ngadena Yolande Sandrine& Tchoupou, Tchinda Huguette…[et al.]. 2019. Nymphaea lotus Linn. (Nymphaeaceae) Alleviates Sexual Disability in L-NAME Hypertensive Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151382
Modern Language Association (MLA)
Kameni, Poumeni Mireille…[et al.]. Nymphaea lotus Linn. (Nymphaeaceae) Alleviates Sexual Disability in L-NAME Hypertensive Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151382
American Medical Association (AMA)
Kameni, Poumeni Mireille& Djomeni Dzeufiet, Paul Désiré& Bilanda, Danielle Claude& Mballa, Marguerite Francine& Mengue, Ngadena Yolande Sandrine& Tchoupou, Tchinda Huguette…[et al.]. Nymphaea lotus Linn. (Nymphaeaceae) Alleviates Sexual Disability in L-NAME Hypertensive Male Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151382