BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling
Joint Authors
Ghosh, Mrinmoy
Huynh, Do Luong
Koh, Hyebin
Chandimali, Nisansala
Zhang, Jiao Jiao
Kim, Nameun
Kang, Tae Yoon
Gera, Meeta
Park, Yang-Ho
Kwon, Taeho
Jeong, Dong Kee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pancreatic cancer has a poor survival rate as compared to other types of cancer.
Surface marker CD44 plays important role in epithelial-mesenchymal transition and cancer stem cell phenotype.
Therefore, targeting CD44 positive pancreatic cancer cells might enhance therapies effectiveness.
Our previous studies indicated the antitumorigenesis effect of BRM270 in osteosarcoma, lung cancer, and glioblastoma; however there is no evidence on BRM270 impacts on pancreatic cancer growth.
In this study, we investigated the effect of BRM270 on the isolated CD44 positive pancreatic ductal adenocarcinoma cells (CD44+ PDAC).
Results showed that CD44 positive cells undergo apoptosis induced by BRM270.
Moreover, BRM270 also inhibits stemness and metastasis traits in CD44+ PDAC via Sonic hedgehog signaling pathway and SALL4 expression.
In vivo study indicated that tumor growth derived from CD44+ PDAC was suppressed as daily uptake by BRM270 5 mg/kg.
These data suggest the alternative approach in antipancreatic tumorigenesis via herbal plants extract and selectively targeting CD44+ PDAC cells in tumor.
American Psychological Association (APA)
Huynh, Do Luong& Koh, Hyebin& Chandimali, Nisansala& Zhang, Jiao Jiao& Kim, Nameun& Kang, Tae Yoon…[et al.]. 2019. BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151385
Modern Language Association (MLA)
Huynh, Do Luong…[et al.]. BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151385
American Medical Association (AMA)
Huynh, Do Luong& Koh, Hyebin& Chandimali, Nisansala& Zhang, Jiao Jiao& Kim, Nameun& Kang, Tae Yoon…[et al.]. BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151385