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Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging
Joint Authors
Kaiho, Yasuhiro
Iwamura, Hiromichi
Anan, Go
Ito, Jun
Satani, Nozomi
Matsuura, Tomonori
Tamura, Ryo
Murakami, Kazuhiro
Koyama, Kaneki
Sato, Makoto
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In contrast to bone scan and computed tomography (CT), which depend on osteoblastic response to detect bone metastasis, whole-body magnetic resonance imaging (WB-MRI) may be able to directly detect viable tumors.
A 75-year-old male who had progressive metastatic prostate cancer during primary androgen deprivation therapy was referred to our hospital.
Although bone scan and CT showed multiple bone metastases, WB-MRI suggested nonviable bone metastasis and viable tumor of the primary lesion.
Prostate needle biopsy demonstrated viable prostate cancer cells from 10 of 12 cores.
In contrast, CT-guided needle biopsy from bone metastasis of the lumbar vertebra revealed no malignant cells.
Based on these findings, we reasoned that viable tumor cells inducing disease progression may primarily exist in the primary lesions and not in the metastatic lesions, and combined prostate radiotherapy and systemic hormonal therapy resulted in successful clinical response and disease control.
The use of WB-MRI to detect viable disease lesions may enable us to design optimal treatment strategies for patients with metastatic castration-resistant prostate cancer.
American Psychological Association (APA)
Iwamura, Hiromichi& Kaiho, Yasuhiro& Ito, Jun& Anan, Go& Satani, Nozomi& Matsuura, Tomonori…[et al.]. 2018. Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging. Case Reports in Urology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1151391
Modern Language Association (MLA)
Iwamura, Hiromichi…[et al.]. Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging. Case Reports in Urology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1151391
American Medical Association (AMA)
Iwamura, Hiromichi& Kaiho, Yasuhiro& Ito, Jun& Anan, Go& Satani, Nozomi& Matsuura, Tomonori…[et al.]. Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging. Case Reports in Urology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1151391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151391