Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents
Joint Authors
Song, Chang Hyun
Lee, Sol
Song, Phil Hyun
Lee, Young-Joon
Ku, Sae-Kwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Green tea is generally considered safe, but there have been concerns regarding side effects relating to the main component, catechins, especially hepatotoxicities.
We have previously shown beneficial effects of fermented green tea with Aquilariae Lignum (fGT) via an oral route in diabetic and obese models.
Thus, the toxicological safety of fGT was assessed at limited oral doses for a rodent.
Mice or rats of both genders were orally administered distilled water as a control and fGT at 2.0, 1.0, and 0.5 g/kg.
There were no mortalities or gross abnormalities in the fGT groups for 2 weeks following the single oral dose in mice.
No fGT-relevant abnormalities were found in postmortem and histopathological examinations, suggesting LD50 of fGT at more than 2.0 g/kg with no specific target organs.
There were also no fGT-relevant mortalities or abnormal signs in the repeated oral dose for 13 weeks in rats.
In the fGT groups, no body weight changes or daily metabolic changes were found, and hematological and serum biochemical ranges were normal.
The postmortem and histopathological examinations revealed few fGT-related abnormalities in most of the organs including the liver, although slight lymphoid cell hyperplasia in the lymph node was observed in a few rats with fGT at 2.0 g/kg.
This may be secondary to increased immune response to the highest dose because there were no histopathological lesions or organ weight changes.
It suggests nontoxic safety of fGT at up to 2.0 g/kg, which provides useful information for clinical use.
American Psychological Association (APA)
Lee, Sol& Song, Phil Hyun& Lee, Young-Joon& Ku, Sae-Kwang& Song, Chang Hyun. 2019. Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151421
Modern Language Association (MLA)
Lee, Sol…[et al.]. Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1151421
American Medical Association (AMA)
Lee, Sol& Song, Phil Hyun& Lee, Young-Joon& Ku, Sae-Kwang& Song, Chang Hyun. Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151421