Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine
Joint Authors
Saad, Bashar
Touzani, Soumaya
Imtara, Hamada
Kmail, Abdalsalam
Badiaa, Lyoussi
Khader, Mira
Hamarshi, Hadeel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this in vitro study is to characterize the phenolic compounds of twelve honey samples collected from different locations in Palestine (H1-6) and Morocco (H7-12) and to evaluate their cytotoxic and cytostatic effects in cells from the human colorectal carcinoma cell line HCT-116 and breast cancer cell line MCF-7.
Quantitative HPLC analysis revealed nine phenolic compounds in three Moroccan honey samples, namely, syringic acid, tannic acid, caffeic acid, ferulic acid, coumaric acid, gallic acid, rosmarinic acid, epicatechin, and pyrogallol.
Syringic acid, abundant in numerous types of honey with strong antioxidant capacities, was present at values ranging between 0.10 mg/100 g and 1.24 mg/100 g of Daghmos (H11) and Kabbar (H10) samples, respectively.
No significant reductions in cell viability were observed in both cell lines treated with the Palestinian samples as measured with MTT assay.
Significant cytostatic effects were after treatment of HCT cells with Morar honey H1 with IC50 of 1789 μg/ml.
Three Moroccan samples, H7 (Zaâtar), H9 (Bochnikha), and H10 (Kabbar), showed slight, but significant cytostatic effects in HCT cells.
A strong correlation was observed between cytostatic activity of MCF cells and antioxidant content (phenols, flavonoids, and flavonol).
Furthermore, a strong negative correlation was detected between the cytostatic activity in HCT cells and the contents of syringic acid (r= -0.756) and tannic acid (r= -0.610).
These results indicate that the traditionally known anticancer effects of honey might be mediated in part through cytostatic effects.
American Psychological Association (APA)
Imtara, Hamada& Kmail, Abdalsalam& Touzani, Soumaya& Khader, Mira& Hamarshi, Hadeel& Saad, Bashar…[et al.]. 2019. Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151432
Modern Language Association (MLA)
Imtara, Hamada…[et al.]. Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1151432
American Medical Association (AMA)
Imtara, Hamada& Kmail, Abdalsalam& Touzani, Soumaya& Khader, Mira& Hamarshi, Hadeel& Saad, Bashar…[et al.]. Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151432