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Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity
Joint Authors
Laurenti, Márcia Dalastra
Passero, Luiz Felipe Domingues
Santos, Beatriz Mendes
Bezerra-Souza, Adriana
Aragaki, Sonia
Umehara, Eric
Ghilardi Lago, João Henrique
Ribeiro, Susan Pereira
Rodrigues, Eliana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus.
Different clinical outcomes can be observed depending on the parasite species and patient’s health condition.
The outcomes can range from single cutaneous lesions to lethal visceral form.
The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used.
Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial.
These detrimental features make fundamental the discovery and characterization of new drugs or plant extracts with leishmanicidal effects.
Brazil is a well-known country for its biodiversity.
Additionally, the common knowledge inherited for generations in small villages makes Brazil a source of new information and resources for the discovery and development of new drugs.
Based on ethnopharmacology, elderlies were interviewed about plants they commonly used for skin diseases and infections.
Five native plants from Atlantic forest were indicated; EtOH and n-hexane extracts were prepared with the vegetative organs of the plants and assayed against promastigote and amastigote forms of L.
(L.) amazonensis.
The major molecules of each extract were detected using qualitative nuclear magnetic resonance.
Among all tested extracts, the n-hexane extract from the leave of Eugenia uniflora (Myrtaceae), enriched in myricitrin and quercitrin flavonoids, was the most effective against L.
(L.) amazonensis amastigotes.
This data supports the ethnopharmacology approach as a successful tool for the discovery of new drugs with leishmanicidal effects.
American Psychological Association (APA)
Santos, Beatriz Mendes& Bezerra-Souza, Adriana& Aragaki, Sonia& Rodrigues, Eliana& Umehara, Eric& Ghilardi Lago, João Henrique…[et al.]. 2019. Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151437
Modern Language Association (MLA)
Santos, Beatriz Mendes…[et al.]. Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151437
American Medical Association (AMA)
Santos, Beatriz Mendes& Bezerra-Souza, Adriana& Aragaki, Sonia& Rodrigues, Eliana& Umehara, Eric& Ghilardi Lago, João Henrique…[et al.]. Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151437