Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial
Joint Authors
Zhou, Fuling
Wei, Yongchang
Pan, Yunbao
Ding, Lu
Xu, Lulin
Jin, Yanxia
Sattar, Safat
Tan, Yuxin
Yang, Tian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Shengxuening (SXN) tablet is extracted from the excrement of the silkworm and has effects on hematopoiesis.
The main components of SXN are chlorophyll derivatives and sodium iron chlorophyllin (SIC).
The present study aims to investigate the efficiency and safety of SXN on iron deficiency anemia.
This phase IV, multicenter, open-label, randomized clinical trial was conducted in 31 hospitals in China from June 2001 to April 2002.
Adults and children were randomly divided into low-dose (L-SXN), medium-dose (M-SXN), and high-dose (H-SXN) groups, respectively.
The course of treatment was 1 month.
Peripheral hemogram levels and iron status were examined before and after treatment.
Adults in all three dose groups demonstrated a significant increase in hemoglobin (HGB) concentration.
Children who received SXN treatment in medium and high doses also demonstrated increased HGB concentration.
Reticulocyte counts increased at the end of treatment in the M-SXN and H-SXN adult groups and in the M-SXN child group.
For both children and adults, SXN in the three dose groups was found to significantly elevate red blood cell level, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration.
The total effective rate in the SXN-treated group reached 84.8%.
The incidence of adverse events was 4.07%.
The most common side effects were nausea (2.83%), diarrhea (0.74%), and rash (0.25%).
SXN was proved to be efficient and safe for adults and children with iron deficiency anemia.
American Psychological Association (APA)
Ding, Lu& Xu, Lulin& Jin, Yanxia& Wei, Yongchang& Pan, Yunbao& Sattar, Safat…[et al.]. 2019. Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151456
Modern Language Association (MLA)
Ding, Lu…[et al.]. Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151456
American Medical Association (AMA)
Ding, Lu& Xu, Lulin& Jin, Yanxia& Wei, Yongchang& Pan, Yunbao& Sattar, Safat…[et al.]. Efficacy of SXN in the Treatment of Iron Deficiency Anemia: A Phase IV Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151456