BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE-- Mice
Joint Authors
Zhang, Junping
Wang, Shuo
Pang, Shu-chao
Chen, Mei-ling
Wang, Yuan-yuan
Jia, Hui-yun
Bi, Li-yuan
Wang, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
BuShenKangShuai tablet (BSKS) is a Chinese herbal compound, which has been used to treat nonalcoholic fatty liver disease and cardiovascular diseases in clinic for over four decades.
This study intends to explore whether BSKS administration can alleviates hepatic steatosis via improving liver adiponectin resistance in ApoE-/- mice.
ApoE-/- mice were fed with western-type diet for 6 weeks and then were administrated with BSKS or atorvastatin for 6 weeks by gavage, and then blood and liver were collected for analysis.
The results showed that BSKS attenuated hepatic steatosis, decreased blood lipids, and increased the serum level of adiponectin.
We also found that adiponectin resistance in the liver was improved by BSKS, while the expression of TLR4 and NF-κB p65 was inhibited, followed by the suppression of proinflammatory mediators of TNF-α.
Our data provided evidence that BSKS was able to alleviate hepatic steatosis in vivo.
The underlying mechanism of BSKS was focused on improving liver adiponectin resistance, thereby regulating dyslipidemia and inhibiting inflammatory signaling pathway.
American Psychological Association (APA)
Pang, Shu-chao& Wang, Shuo& Chen, Mei-ling& Zhang, Junping& Wang, Yuan-yuan& Jia, Hui-yun…[et al.]. 2019. BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE-- Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151525
Modern Language Association (MLA)
Pang, Shu-chao…[et al.]. BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE-- Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151525
American Medical Association (AMA)
Pang, Shu-chao& Wang, Shuo& Chen, Mei-ling& Zhang, Junping& Wang, Yuan-yuan& Jia, Hui-yun…[et al.]. BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE-- Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151525