Temporal Change in Blood Group after Bone Marrow Transplant: A Case of Successful ABO-Incompatible Deceased Donor Transplant

Abstract EN

ABO-incompatible kidney transplantation has been successfully utilised in a deceased donor and living donor kidney transplantation to improve organ utilisation and decrease waiting times.

We describe a case of a successful, unanticipated ABO-incompatible donation after cardiac death (DCD) kidney transplant in a patient who had a previous ABOi haematopoietic stem cell transplant (HSCT) and had reverted to his original blood group B, after matching as a blood group A recipient with a blood group A donor.

The recipient was unsensitized with a cPRA which was 0% and no donor-specific antibodies and zero HLA mismatch.

An urgent anti-A titre was 1 : 2.

Given the low antibody titres, we proceeded to transplantation.

The patient developed delayed graft function and required dialysis on postoperative day 1 and day 2.

The creatinine fell spontaneously on day 5, with progressively increased urine output and stable graft function on discharge at day 6.

Anti-A titres were 1 : 1 on serial postoperative measurements.

There were no rejection episodes, and the patient has a functioning graft at 16 months posttransplant.

We describe a rare case in which the blood group can change after stem cell transplant and should be checked.

We also demonstrate that a DCD ABOi transplant in the context of low anti-A titres for a patient with previous ABOi stem cell transplant can be performed successfully with standard immunosuppression.