Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?
Joint Authors
Prikis, Marios
MacDougall, Julie
Narasimhadevara, Nina
Source
Case Reports in Transplantation
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Over the last decades, proton pump inhibitors (PPIs) have been widely used as the mainstay for treatment and prevention of gastrointestinal side effects, gastroesophageal reflux, and peptic ulcer disease.
However, their safety profile has come into question recently after reports relating them to several side effects as well as kidney disease.
Omeprazole, one of the mainly used PPIs, is almost entirely metabolized by the liver but the resulting metabolites are renally excreted.
These metabolites may inhibit cytochrome P450 2C19 (CYP2C19) and cytochrome P450 3A4 (CYP3A4) reversibly, but as recent evidence suggests, they may also be involved in causing kidney disease.
In the setting of renal dysfunction, these metabolites will not be excreted from the body and will accumulate further causing kidney damage and inhibiting CYP enzymes to a greater extent.
Abnormally high serum prolactin levels leading to galactorrhea may be the result of such an accumulation.
To our knowledge, there have been only three previously reported cases of PPI-induced galactorrhea in the literature but none in a kidney transplant recipient.
In patients with established kidney disease and reduced glomerular filtration rate like kidney transplant recipients, the use of PPIs should be thoroughly assessed.
Reduced clearance of their metabolites may lead to progression of the kidney disease and lead to more unwanted side effects.
We present a case of a female kidney transplant recipient with worsening allograft function who presented with sudden galactorrhea and hyperprolactinemia while on a high-dose omeprazole for gastroesophageal reflux disease.
American Psychological Association (APA)
Prikis, Marios& MacDougall, Julie& Narasimhadevara, Nina. 2020. Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?. Case Reports in Transplantation،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151701
Modern Language Association (MLA)
Prikis, Marios…[et al.]. Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?. Case Reports in Transplantation No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1151701
American Medical Association (AMA)
Prikis, Marios& MacDougall, Julie& Narasimhadevara, Nina. Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe?. Case Reports in Transplantation. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151701