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Extract of Rhus verniciflua Stokes Induces p53-Mediated Apoptosis in MCF-7 Breast Cancer Cells
Joint Authors
Kim, Min Sung
Lee, Jang-Cheon
An, Won G.
Kim, Jung Hoon
Lee, Chul Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rhus verniciflua Stokes has long been used as a food supplement and traditional herbal medicine for various ailments in East Asia.
We evaluated the anticancer effects of Rhus verniciflua Stokes extract (RVSE) on MCF-7 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, annexin V/7-AAD staining, and western blotting.
In addition, the gallic acid content of RVSE was assayed using high-performance liquid chromatography.
RVSE inhibited the growth of MCF-7 cells in a dose-dependent manner by inducing apoptosis in the sub-G1 phase.
RVSE also significantly increased the number of apoptotic cells and increased the expression of p53 and p21 in a dose-dependent manner.
Furthermore, RVSE treatment increased the Bax:Bcl-2 ratio and the levels of apoptosis-related factors, such as cleaved caspase-3 and -9 and PARP, in MCF-7 cells.
Our findings suggest that the proapoptotic effect of RVSE on MCF-7 cells is mediated by p53, p21, and the intrinsic mitochondrial cascade.
Thus, RVSE shows promise for the prevention and treatment of breast cancer.
American Psychological Association (APA)
Kim, Min Sung& Lee, Chul Won& Kim, Jung Hoon& Lee, Jang-Cheon& An, Won G.. 2019. Extract of Rhus verniciflua Stokes Induces p53-Mediated Apoptosis in MCF-7 Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151704
Modern Language Association (MLA)
Kim, Min Sung…[et al.]. Extract of Rhus verniciflua Stokes Induces p53-Mediated Apoptosis in MCF-7 Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151704
American Medical Association (AMA)
Kim, Min Sung& Lee, Chul Won& Kim, Jung Hoon& Lee, Jang-Cheon& An, Won G.. Extract of Rhus verniciflua Stokes Induces p53-Mediated Apoptosis in MCF-7 Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151704