Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide
Joint Authors
Wojciechowski, David
Abou Diwan, Elizabeth
Patel, Ankit B.
Cuenca, Alex G.
Elias, Nahel
Gilligan, Hannah M.
Heher, Eliot
Leaf, David E.
Safa, Kassem
Source
Case Reports in Transplantation
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Among patients with short bowel syndrome who commonly have kidney disease, kidney transplantation remains challenging.
We describe the clinicopathologic course of a 59-year old man with short bowel syndrome secondary to Crohn’s disease who underwent a deceased donor kidney transplant that was complicated by recurrent acute kidney allograft injury due to volume depletion from diarrhea, ultimately requiring the placement of permanent intravenous access for daily volume expansion at home resulting in the recovery of allograft function.
Teduglutide treatment at 1.8 years post-transplant led to a dramatic decrease in diarrhea.
A literature review of similar cases yielded 18 patients who underwent 19 kidney transplants.
Despite high rates of complications, at the time of last follow-up (median 2.1 years [0.04-7]), 94% of the patients were still alive and 89% had functioning allografts, with a median eGFR of 37.5 [14-122] ml/min/1.73m2.
In conclusion, despite high rates of complications, kidney transplantation in patients with short bowel syndrome is associated with acceptable short- and midterm outcomes.
Further, we report for the first time the effects of the glucagon-like peptide-2 analogue teduglutide for short bowel syndrome in a kidney transplant recipient.
American Psychological Association (APA)
Abou Diwan, Elizabeth& Patel, Ankit B.& Cuenca, Alex G.& Elias, Nahel& Gilligan, Hannah M.& Heher, Eliot…[et al.]. 2020. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Reports in Transplantation،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151711
Modern Language Association (MLA)
Abou Diwan, Elizabeth…[et al.]. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Reports in Transplantation No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1151711
American Medical Association (AMA)
Abou Diwan, Elizabeth& Patel, Ankit B.& Cuenca, Alex G.& Elias, Nahel& Gilligan, Hannah M.& Heher, Eliot…[et al.]. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Reports in Transplantation. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1151711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151711