Tiotropium for the Treatment of Asthma: Patient Selection and Perspectives
Joint Authors
Mcivor, R. Andrew
Chari, V. Madhu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Asthma is a chronic disease of airway inflammation with a large global burden.
Despite established, guideline-based stepwise therapy, a significant proportion of patients remain symptomatic and poorly controlled.
As such, there is a need for additional safe, effective, convenient, and cost-effective therapies that can be broadly applied across a range of asthma phenotypes.
Tiotropium is a long-acting muscarinic antagonist (LAMA) that leads to bronchodilation by blocking endogenous acetylcholine receptors in the airways.
Tiotropium has long been approved for the treatment of chronic obstructive pulmonary disease, and it has recently been recognized for its safety and efficacy in improving lung function and controlling asthma.
Evidence from several Phase III trials in the adult and paediatric population has shown that tiotropium is well tolerated and significantly improves a range of endpoints as an add-on treatment to ICS therapy, regardless of baseline characteristics and clinical phenotypes.
Consequently, regulatory authorities worldwide have recently licensed tiotropium as the only LAMA approved for the treatment of asthma.
This review provides an overview of safety and efficacy data and discusses the use of tiotropium in patients across the range of asthma severities, ages, and phenotypes.
American Psychological Association (APA)
Chari, V. Madhu& Mcivor, R. Andrew. 2018. Tiotropium for the Treatment of Asthma: Patient Selection and Perspectives. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1151771
Modern Language Association (MLA)
Chari, V. Madhu& Mcivor, R. Andrew. Tiotropium for the Treatment of Asthma: Patient Selection and Perspectives. Canadian Respiratory Journal No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1151771
American Medical Association (AMA)
Chari, V. Madhu& Mcivor, R. Andrew. Tiotropium for the Treatment of Asthma: Patient Selection and Perspectives. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1151771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151771