ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Xi
Li, Qian
Liu, Ruming
He, Jin
Wu, Di
Wang, Yun
Zhang, Jun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The beta-2 adrenergic receptor (ADRB2) Arg16Gly polymorphism may alter the bronchodilation response to long-acting beta2-agonists, thereby influencing the clinical effectiveness of LABAs plus corticosteroids (ICS) treatment.
But the results of individual studies are inconclusive.
Methods.
A systematic search was conducted in PubMed, Embase, the Cochrane Database, WHO International Clinical Trials Registry Platform, Chinese National Knowledge Infrastructure, Wanfang, Chinese BioMedical Literature Database, and VIP databases.
The meta-analysis was performed with RevMan statistical software (version 5.2), and potential publication bias was estimated by Egger’s test using STATA (version 12.0), with p<0.05 indicating significant publication bias.
Results.
We found 5 cohort studies with a total of 632 patients and included them in the meta-analysis.
There are no significant differences in pulmonary function response between patients with the Arg/Arg and Arg/Gly phenotype (SMD −0.04, 95% CI −0.45 to 0.37; p=0.84).
There were also no significant differences in the pulmonary function response between patients with the Arg/Arg and Gly/Gly phenotype (MD −0.03, 95% CI −0.07 to 0.02; p=0.28).
Conclusions.
Our systematic review and meta-analysis suggest that ADRB2 Arg16Gly polymorphism is not associated with pulmonary response to asthma treatment with ICS plus LABAs.
American Psychological Association (APA)
Wang, Xi& Li, Qian& Liu, Ruming& He, Jin& Wu, Di& Wang, Yun…[et al.]. 2018. ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1151803
Modern Language Association (MLA)
Wang, Xi…[et al.]. ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1151803
American Medical Association (AMA)
Wang, Xi& Li, Qian& Liu, Ruming& He, Jin& Wu, Di& Wang, Yun…[et al.]. ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1151803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151803