Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats
Joint Authors
Chang, Yanxu
Gao, Xiu-Mei
Li, Jin
He, Jun
Yu, Xie-an
Chen, Shujing
Li, Zhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Embelin exhibits the broad bioactivities such as antitumor, antifertility, antidiabetic, anti-inflammatory, antioxidant, anticonvulsant, anxiolytic, antimicrobial, and hepatoprotective activity.
In order to further understand the pharmacokinetic characteristics and oral bioavailability of embelin in vivo, the concentration of embelin in rat plasma was determined by a sensitive high-performance liquid chromatography with diode array detector (HPLC-DAD).
The preparation of samples was accomplished by a simple precipitating protein with methanol.
Emodin was selected as the internal standard (IS).
Embelin and IS were completely separated on an analytical column (Extend-C18, 4.6 × 250 mm, 5 μm) using 0.1% phosphoric acid in methanol and 0.1% phosphoric acid in aqueous solution (90:10, v/v) as the mobile phase.
The lower limit of quantification was 0.15 μg/mL.
Oral bioavailability of embelin was 30.2 ± 11.9%.
This study could provide the information about pharmacokinetics and oral bioavailability of embelin, which was useful to assess the clinic efficacy and safety and promote further development of embelin.
American Psychological Association (APA)
Li, Zhen& Chen, Shujing& Yu, Xie-an& Li, Jin& Gao, Xiu-Mei& He, Jun…[et al.]. 2019. Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151833
Modern Language Association (MLA)
Li, Zhen…[et al.]. Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1151833
American Medical Association (AMA)
Li, Zhen& Chen, Shujing& Yu, Xie-an& Li, Jin& Gao, Xiu-Mei& He, Jun…[et al.]. Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1151833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151833