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Risk of Cardiovascular Events Associated with Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis
Joint Authors
Jing, Xia
Li, Yufeng
Xu, Jianying
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The cardiovascular (CV) safety of inhaled corticosteroids (ICSs) in chronic obstructive pulmonary disease (COPD) is controversial because different studies have suggested that ICSs either increase or reduce the risk of CV events in COPD patients.
In this meta-analysis, we assess the CV safety of ICS therapy in COPD.
Methods.
A meta-analysis of randomized, double-blind, parallel-group, placebo-controlled trials of ICS treatment for COPD that include at least 4 weeks of follow-up was performed.
A random-effects model was used to evaluate the effects of ICS treatment on CV events.
CV events were documented in each trial, and the relative risk (RR) and 95% confidence intervals (CIs) for ICSs were estimated.
Results.
Thirty-one trials were included in this meta-analysis.
The risk of CV events was not different between ICS-treated and control groups (RR: 0.99; 95% CI: 0.93 to 1.06; P=0.801).
In a subgroup analysis, there were no significant differences in CV events between an ICS combined with long-acting β2 agonist (LABA) (ICS + LABA) group and an LABA-only group (RR: 1.00; 95% CI: 0.90 to 1.10; P=0.930), as well as between a combination group (ICS + LABA) and a long-acting muscarinic antagonist (LAMA) combined with LABA (LAMA + LABA) group (RR: 0.78; 95% CI: 0.39 to 1.55; P=0.473).
In addition, there was no difference in the risk of CV events between ICS treatment and control groups (RR: 0.99; 95% CI: 0.90 to 1.09; P=0.872).
Conclusions.
These results demonstrate that ICSs do not increase the risk of CV events in COPD patients.
American Psychological Association (APA)
Jing, Xia& Li, Yufeng& Xu, Jianying. 2018. Risk of Cardiovascular Events Associated with Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1151861
Modern Language Association (MLA)
Jing, Xia…[et al.]. Risk of Cardiovascular Events Associated with Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Canadian Respiratory Journal No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1151861
American Medical Association (AMA)
Jing, Xia& Li, Yufeng& Xu, Jianying. Risk of Cardiovascular Events Associated with Inhaled Corticosteroid Treatment in Patients with Chronic Obstructive Pulmonary Disease: A Meta-Analysis. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1151861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151861