Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia
Joint Authors
Kawana, Akihiko
Murohashi, Kota
Hara, Yu
Shinada, Kanako
Nagai, Kenjiro
Shinkai, Masaharu
Kaneko, Takeshi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis.
The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP).
Materials and Methods.
Serum HO-1 levels of newly diagnosed or untreated patients with IP were measured at hospitalization.
We evaluated the relationships between serum HO-1 and other serum biomarkers, high resolution CT (HRCT) findings, and hospital mortality.
Results.
Twenty-eight patients with IP, including 14 having an acute exacerbation (AE) and 14 not having an AE, were evaluated.
The patients having an AE had significantly higher HO-1 levels than those not having an AE (53.5 ng/mL vs.
24.1 ng/mL; p<0.001), and the best cut-off level to discriminate between having an AE or not having an AE was 41.6 ng/mL.
Serum HO-1 levels were positively correlated with serum levels of surfactant protein-D (r=0.66, p<0.001) and the ground glass opacity score (calculated from HRCT; r=0.40, p=0.036).
Patients who subsequently died in hospital had presented with significantly higher HO-1 levels than those who did not die in hospital (64.8 ng/mL vs.
32.0 ng/mL; p=0.009).
Conclusion.
Serum HO-1 may serve as a useful biomarker for detecting AE or predicting hospital mortality in patients with IP.
American Psychological Association (APA)
Murohashi, Kota& Hara, Yu& Shinada, Kanako& Nagai, Kenjiro& Shinkai, Masaharu& Kawana, Akihiko…[et al.]. 2018. Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1151865
Modern Language Association (MLA)
Murohashi, Kota…[et al.]. Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia. Canadian Respiratory Journal No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1151865
American Medical Association (AMA)
Murohashi, Kota& Hara, Yu& Shinada, Kanako& Nagai, Kenjiro& Shinkai, Masaharu& Kawana, Akihiko…[et al.]. Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1151865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151865