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Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats
Joint Authors
Soliman, Amel M.
Mohamed, Ayman S.
Ibrahim, Walaa Mohammed
Zaki, Nashwah Ismail
Ali, Sara Bayoumi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The present study aimed to assess the effectiveness of clam extract in combination with atorvastatin against experimentally hyperlipidemia in rats.
Method.
Forty male rats were divided into 5 groups (8 rats /group): control, high fat diet (HFD), atorvastatin (AROR), clam extract (CE), and ATOR + CE.
Results.
The treatments with ATOR and /or CE significantly reduced the body weight gain, AST, ALT, ALP, TL, TC, TG, LDL-C, urea, creatinine, and uric acid levels while they increased total proteins, albumin, and HDL-C.
The treatment with ATOR only did not cause any significant change in CK and MDA along with antioxidant system, while the treatment with CE alone or with ATOR significantly decreased CK and MDA accompanied by improving the antioxidant system.
Conclusion.
Combination of CE extract with atorvastatin improved the hyperlipidemic efficacy and reduced undesirable side effects especially on muscle.
American Psychological Association (APA)
Mohamed, Ayman S.& Ibrahim, Walaa Mohammed& Zaki, Nashwah Ismail& Ali, Sara Bayoumi& Soliman, Amel M.. 2019. Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151889
Modern Language Association (MLA)
Mohamed, Ayman S.…[et al.]. Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151889
American Medical Association (AMA)
Mohamed, Ayman S.& Ibrahim, Walaa Mohammed& Zaki, Nashwah Ismail& Ali, Sara Bayoumi& Soliman, Amel M.. Effectiveness of Coelatura aegyptiaca Extract Combination with Atorvastatin on Experimentally Induced Hyperlipidemia in Rats. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151889