In Vitro Antioxidant and In Vivo Lipid-Lowering Properties of Zingiber officinale Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study
Joint Authors
Harnafi, Hicham
Bekkouch, Oussama
Harnafi, Mohamed
Touiss, Ilham
Khatib, Saloua
Alem, Chakib
Amrani, Souliman
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Over the past decades, cardiovascular diseases have become the leading cause of death all over the world, and among these diseases there is atherosclerosis caused mainly by an increase in plasmatic cholesterol levels and by strong oxidation caused by free radicals.
For these reasons and others, we explored in this report the hypolipidemic and the antioxidant effects of Zingiber officinale crude aqueous and methanolic extract.
The hypolipidemic study was carried out in high-fat-fed mice model.
Animals were subdivided into four groups and were orally treated with the aqueous extract once daily for twelve weeks at two doses: 250 and 500 mg/Kg.
During the treatment, the body weight, total cholesterol, triglycerides, and high-density lipoproteins have been defined every four weeks.
The antioxidant activity has been studied using radical scavenging activity, β-carotene bleaching, reducing power assay, and the TBARs tests.
The daily oral administration of the extracts for twelve weeks significantly improved the lipid profile in a dose-dependent manner, from the first until the twelfth week, and also showed a significant antioxidant effect.
These findings may be potentially contributive to the validation of the medicinal use of Z.
officinale to treat hyperlipidemia and cardiovascular complications.
American Psychological Association (APA)
Bekkouch, Oussama& Harnafi, Mohamed& Touiss, Ilham& Khatib, Saloua& Harnafi, Hicham& Alem, Chakib…[et al.]. 2019. In Vitro Antioxidant and In Vivo Lipid-Lowering Properties of Zingiber officinale Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151906
Modern Language Association (MLA)
Bekkouch, Oussama…[et al.]. In Vitro Antioxidant and In Vivo Lipid-Lowering Properties of Zingiber officinale Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151906
American Medical Association (AMA)
Bekkouch, Oussama& Harnafi, Mohamed& Touiss, Ilham& Khatib, Saloua& Harnafi, Hicham& Alem, Chakib…[et al.]. In Vitro Antioxidant and In Vivo Lipid-Lowering Properties of Zingiber officinale Crude Aqueous Extract and Methanolic Fraction: A Follow-Up Study. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151906