Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review
Joint Authors
Mohd Ramli, Elvy Suhana
Raja Kumar, Sivanesan
Abdul Nasir, Nurul Alimah
Ismail, Nafeeza Hj Mohd
Nur Azlina, Mohd Fahami
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Metabolic syndrome (MetS), which consists of cluster of conditions, hypertension, hyperlipidemia, hyperglycemia, and visceral obesity, is affecting population worldwide.
Studies have shown that plant derived flavonoids have the ability to alleviate MetS.
Naringin is a type of glycoside flavonoid found in most plant and it plays a critical role in the treatment of MetS due to its antioxidant activity and ability to regulate cytokines.
Methods.
A systematic review was done to study the effects of naringin on the metabolic diseases using electronic databases which include Ovid and Scopus using specific descriptors published from the year 2010 till present to provide updated literature on this field.
The articles were assessed and chosen based on the criteria in which the mechanisms and effects of naringin on different metabolic diseases were reported.
Results.
Thirty-four articles were identified which referred to the studies that correspond to the previously stated criteria.
Subsequently after screening for the articles that were published after the year 2010, finally, 19 articles were selected and assessed accordingly.
Based on the assessment, naringin could alleviate MetS by reducing visceral obesity, blood glucose, blood pressure, and lipid profile and regulating cytokines.
Conclusions.
Naringin is an antioxidant that appears to be efficacious in alleviating MetS by preventing oxidative damage and proinflammatory cytokine release.
However, the dosage used in animal studies might not be achieved in human trials.
Thus, adequate investigation needs to be conducted to confirm naringin’s effects on humans.
American Psychological Association (APA)
Raja Kumar, Sivanesan& Mohd Ramli, Elvy Suhana& Abdul Nasir, Nurul Alimah& Ismail, Nafeeza Hj Mohd& Nur Azlina, Mohd Fahami. 2019. Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151925
Modern Language Association (MLA)
Raja Kumar, Sivanesan…[et al.]. Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1151925
American Medical Association (AMA)
Raja Kumar, Sivanesan& Mohd Ramli, Elvy Suhana& Abdul Nasir, Nurul Alimah& Ismail, Nafeeza Hj Mohd& Nur Azlina, Mohd Fahami. Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1151925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151925