![](/images/graphics-bg.png)
Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease
Joint Authors
Schoenberg, Stefan O.
Akin, Ibrahim
Trinkmann, Frederik
Gawlitza, Joshua
Scheffel, Hans
Fischer, Andreas
Nance, John W.
Henzler, Claudia
Vogler, Nils
Saur, Joachim
Henzler, Thomas
Borggrefe, Martin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria.
However, this does not address the pathophysiological complexity of the disease sufficiently.
Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients.
We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes.
The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration.
Materials and Methods.
Forty-six patients with diagnosed COPD underwent spirometry, body plethysmography, and dose-optimized CT in maximal inspiration and expiration.
Four quantified CT parameters were acquired in inspiration, expiration, and their calculated delta values.
These parameters were correlated with seven established lung function parameters.
Results.
For inspiratory scans, a weak-to-moderate correlation with the lung function parameters was found.
These correlations significantly improved when adding the expiratory scan (p<0.05).
Moreover, some parameters showed a significant correlation only in expiratory datasets.
Calculated delta values showed even stronger correlation with lung function testing.
Conclusions.
Expiratory quantified CT and calculated delta values significantly improve the correlation with lung function parameters.
Thus, an additional expiratory CT may improve image-based phenotyping of patients with COPD.
American Psychological Association (APA)
Gawlitza, Joshua& Trinkmann, Frederik& Scheffel, Hans& Fischer, Andreas& Nance, John W.& Henzler, Claudia…[et al.]. 2018. Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1151929
Modern Language Association (MLA)
Gawlitza, Joshua…[et al.]. Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease. Canadian Respiratory Journal No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1151929
American Medical Association (AMA)
Gawlitza, Joshua& Trinkmann, Frederik& Scheffel, Hans& Fischer, Andreas& Nance, John W.& Henzler, Claudia…[et al.]. Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1151929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151929