Baicalein Inhibits Orthotopic Human Non-Small Cell Lung Cancer Xenografts via SrcId1 Pathway
Joint Authors
Liu, Lumei
Dong, Jingcheng
Zhao, Zhengxiao
Liu, Baojun
Lu, Linwei
Qiu, Jian
Li, Qiuping
Yan, Chen
Jiang, Shan
Mohammadtursun, Nabijan
Ma, Wenjuan
Li, Mihui
Gong, Weiyi
Sun, Jing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Non-small cell lung cancer (NSCLC) is one of the most lethal cancers worldwide.
Inhibitor of differentiation 1 (Id1) is the member mostly linked to tumorigenesis in Id family and a potential molecular target in cancer therapy.
In the current study, we established an orthotopic lung cancer model by injecting athymic nude mice with A549 cells and evaluated the antitumor effect of baicalein and expression of Id1-related proteins in vivo and in vitro.
Micro-CT images showed that tumor volume in baicalein group was significantly reduced.
Western blot analysis revealed that baicalein suppressed the expression of Id1 protein, epithelial-to-mesenchymal transition (EMT) related molecules (N-Cadherin, vimentin), and angiogenesis related protein (VEGF-A), accompanied by upregulation of epithelial markers (such as E-cadherin).
In addition, phosphorylation of upstream molecular Src was significantly restrained after baicalein treatment.
This study firstly demonstrates that baicalein inhibits tumor growth in orthotopic human NSCLC xenografts via targeting Src/Id1 pathway.
American Psychological Association (APA)
Zhao, Zhengxiao& Liu, Baojun& Sun, Jing& Lu, Linwei& Liu, Lumei& Qiu, Jian…[et al.]. 2019. Baicalein Inhibits Orthotopic Human Non-Small Cell Lung Cancer Xenografts via SrcId1 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1151935
Modern Language Association (MLA)
Zhao, Zhengxiao…[et al.]. Baicalein Inhibits Orthotopic Human Non-Small Cell Lung Cancer Xenografts via SrcId1 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1151935
American Medical Association (AMA)
Zhao, Zhengxiao& Liu, Baojun& Sun, Jing& Lu, Linwei& Liu, Lumei& Qiu, Jian…[et al.]. Baicalein Inhibits Orthotopic Human Non-Small Cell Lung Cancer Xenografts via SrcId1 Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1151935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151935