Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction
Joint Authors
Guo, Yi
Mao, Tang-you
Shi, Rui
Sun, Zhongmei
Pei, Wenjing
Wang, Zhibin
Chen, Xiaowei
Zhao, Xingjie
Chen, Chen
Liu, Jiali
Tan, Xiang
Yuan, Wenjing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Qingchang Wenzhong Decoction (QCWZD) is a newly developed, effective traditional Chinese herbal formulation for ulcerative colitis (UC).
In earlier studies, we found that QCWZD could relieve the clinical symptoms of UC patients, reduce inflammation, and improve the intestinal barrier function in dextran sulphate sodium (DSS)-induced UC rats.
However, the relationship between QCWZD and the gut microbiota in colitis was not clarified.
In this study, we established a rat model of DSS-induced UC and then investigated the regulatory effects of QCWZD on the gut microbiota using 16S rRNA analysis.
We also determined the expression of NLRP12 after QCWZD administration.
Our findings suggested that QCWZD administration could modulate gut microbiota composition and selectively promote the protective strains such as Butyricimonas, Blautia, and Odoribacter, whereas the enteric pathogens including Clostridium and Dorea were significantly reduced after QCWZD treatment.
It is noteworthy that QCWZD administration was identified to promote gut microbiota-mediated NLRP12 expression by inhibiting the activity of the TLR4/Blimp-1 axis.
In conclusion, our study supports the potential of QCWZD administration as a beneficial therapeutic strategy for UC.
American Psychological Association (APA)
Sun, Zhongmei& Pei, Wenjing& Guo, Yi& Wang, Zhibin& Shi, Rui& Chen, Xiaowei…[et al.]. 2019. Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1151964
Modern Language Association (MLA)
Sun, Zhongmei…[et al.]. Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1151964
American Medical Association (AMA)
Sun, Zhongmei& Pei, Wenjing& Guo, Yi& Wang, Zhibin& Shi, Rui& Chen, Xiaowei…[et al.]. Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1151964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151964