The effects of estradiol deficiency on the level of lipids and proteins of postmenopause Women

Abstract EN

Aging in women is associated by a major loss in ovarian hormone function and consequently of menopause around the age of 50 years old.

The present study was conducted essentially to evaluate the concentrations of some clotting factors and biochemical parameters in postmenopausal women .

This study included125women, of those, 100 women were post menopause aged between(51- 70),subdivided into four subgroups according to their ages: First group (51-55 years), Second group (56-60 years), Third group (61-65 years), and Fourth group (66-70 years).

Twenty five (25) subjects were premenopausal women, their ages ranged between 20-30 years old and served as a control group.

The results of estradiol hormone (E2) were significantly decrease (p<0.05) in all groups of postmenopausal women in comparison with premenopausal women.

Concerning biochemical alterations, especially lipid profile, they showed a significant increase (p<0.05) in the levels of cholesterol, triglycerides, and low density lipoprotein (LDL) concentrations in all aging women groups in comparison with premenopausal women.

In contrast, levels of high density lipoprotein (HDL) were progressively declined in all aging women compared to the control group.

Regarding to the results of protein electrophoresis, it is found that the levels: albumin, beta globulin, and gamma globulin were significantly increased (p<0.05) in all groups of postmenopausal women.

Values of alpha 1 and alpha 2 globulin pointed out a significant lowering (p<0.05) in most groups of postmenopausal women when matched with their counterparts of premenopausal women (control group).