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Influence of Continuous Training on Atrial Myocytes IK1 and IKAch and on Induction of Atrial Fibrillation in a Rabbit Model
Joint Authors
Yuan, Dou
Zheng, Ping
Tan, Chen
Huang, Si Hui
Li, Dan
Huang, Jian
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Elucidation of mechanisms underlying continuous training-related atrial fibrillation (AF) may inform formulation of novel therapeutic approaches and training method selection.
This study was aimed at assessing mechanisms underlying continuous training-induced AF in an animal model.
Methods.
Healthy New Zealand rabbits were divided into three groups (n=8 each), namely, control (C), and moderate intensity (M), and high intensity (H) continuous training according to treadmill speed.
Atrial size andintrinsic and resting heart rates were measured by transthoracic echocardiography before, and 8 and 12 weeks after training.
Using a Langendorff perfusion system, AF was induced by S1S2 stimulation and the induction rate was recorded.
Atrial IK1 and IKAch ion current densities were recorded using whole-cell patch-clamp technique in isolated atrial myocytes.
Changes in atrial Kir2.1, Kir2.2, Kir3.1, and Kir3.4 mRNA expression were assessed by reverse transcriptase-coupled polymerase chain reaction.
Results.
After 8 and 12 weeks, Groups M and H vs.
Group C had greater (all P<0.05) atrial anteroposterior diameter; greater incidence of AF (60% and 90% vs.
45%, respectively; P<0.05, also between Groups H and M); and greater atrial IKAch current density.
In Group H, Kir2.1 and Kir2.2 mRNA expression in the left and right atria was increased (P<0.05, vs.
Groups C and M) as was left atrial Kir3.1 and Kir3.4 mRNA expression (P<0.05, vs.
Group C).
Conclusion.
In a rabbit model, continuous training enlarges atrial diameter leading to atrial structural and electrical remodeling and increased AF incidence.
American Psychological Association (APA)
Yuan, Dou& Zheng, Ping& Tan, Chen& Huang, Si Hui& Li, Dan& Huang, Jian. 2018. Influence of Continuous Training on Atrial Myocytes IK1 and IKAch and on Induction of Atrial Fibrillation in a Rabbit Model. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1152036
Modern Language Association (MLA)
Yuan, Dou…[et al.]. Influence of Continuous Training on Atrial Myocytes IK1 and IKAch and on Induction of Atrial Fibrillation in a Rabbit Model. Cardiology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1152036
American Medical Association (AMA)
Yuan, Dou& Zheng, Ping& Tan, Chen& Huang, Si Hui& Li, Dan& Huang, Jian. Influence of Continuous Training on Atrial Myocytes IK1 and IKAch and on Induction of Atrial Fibrillation in a Rabbit Model. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1152036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152036