Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation
Joint Authors
Letsas, Konstantinos P.
Tse, Gary
Li, Guangping
Liu, Tong
Korantzopoulos, Panagiotis
Zhang, Nixiao
Dahal, Shristi
Yang, Yajuan
Gong, Mengqi
Chan, Calista Zhuo Yi
Liu, Enzhao
Xu, Gang
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Use of amiodarone (AMIO) in atrial fibrillation (AF) has significant side effects over prolonged periods.
Wenxin Keli (WXKL), a Chinese herb extract, has been shown to be effective in atrial-selective inhibiting peak INa and hence beneficial in treating atrial arrhythmias, including atrial fibrillation.
The aim of this randomized controlled trial was to evaluate potential effects of AMIO plus WXKL on conversion rate and time in patients with recent-onset AF.
Methods.
A total of 41 patients (71 ± 12 years, 44% male) with recent-onset (<48 h) AF eligible for conversion were randomized to receive either intravenous amiodarone (loading dose 5 mg/kg in 1 hour followed by 50 mg/h; n=21) or amiodarone with same dosage plus oral WXKL 18 g thrice daily (n=20) for 24 hours.
Results.
Conversion rate at 24 hours was of no difference between the two groups (75.0% vs.
81.0%, P=0.72); however, conversion time was markedly shorter in the AMIO + WXKL group compared to the AMIO group (291 ± 235 minutes vs.
725 ± 475 minutes, P=0.003).
There were no serious adverse events during the study.
Conclusion.
Administration of amiodarone plus WXKL for recent-onset AF conversion was safe and effective, with faster sinus rhythm restoration compared with amiodarone alone.
American Psychological Association (APA)
Zhang, Nixiao& Tse, Gary& Dahal, Shristi& Yang, Yajuan& Gong, Mengqi& Chan, Calista Zhuo Yi…[et al.]. 2018. Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152065
Modern Language Association (MLA)
Zhang, Nixiao…[et al.]. Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation. Cardiology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1152065
American Medical Association (AMA)
Zhang, Nixiao& Tse, Gary& Dahal, Shristi& Yang, Yajuan& Gong, Mengqi& Chan, Calista Zhuo Yi…[et al.]. Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152065