Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis
Joint Authors
Zheng, Ying-Ying
Ma, Yi-Tong
Xie, Xiang
Xiu, Wen-Juan
Yang, Hai-Tao
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
In-stent restenosis (ISR) remains a common problem following percutaneous coronary intervention (PCI).
However, the best treatment strategy remains uncertain.
There is some controversy over the efficacy of drug-eluting balloons (DEBs) and second-generation drug-eluting stents (DESs) for treating ISR.
Methods.
A meta-analysis was used to compare the efficacy of the DEB and second-generation DES in the treatment of ISR.
The primary endpoint is the incidence of target lesion revascularization (TLR).
The secondary endpoint is the occurrence of target vessel revascularization (TVR), myocardial infarction (MI), all-cause death (ACM), cardiac death (CD), major adverse cardiac events (MACEs), minimum luminal diameter (MLD), late luminal loss (LLL), binary restenosis (BR), and percent diameter stenosis (DS%).
Results.
A total of 12 studies (4 randomized controlled trials and 8 observational studies) including 2020 patients with a follow-up of 6–25 months were included in the present study.
There was a significant difference in the MLD between the two groups during follow-up (P=0.007, RR = 0.23, and 95% CI: 0.06–0.4 mm).
There was no significant difference in LLL, BR, or DS% and the overall incidence of MACEs between the two groups.
Subgroup analysis showed no significant difference in the incidence of primary and secondary endpoints when considering RCTs or observational studies only.
Conclusions.
The efficacy of the DEB and second-generation DES in the treatment of ISR is comparable.
However, our results need further verification through multicenter randomized controlled trials.
American Psychological Association (APA)
Xiu, Wen-Juan& Yang, Hai-Tao& Zheng, Ying-Ying& Ma, Yi-Tong& Xie, Xiang. 2018. Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1152094
Modern Language Association (MLA)
Xiu, Wen-Juan…[et al.]. Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis. Cardiology Research and Practice No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1152094
American Medical Association (AMA)
Xiu, Wen-Juan& Yang, Hai-Tao& Zheng, Ying-Ying& Ma, Yi-Tong& Xie, Xiang. Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1152094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152094