Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry
Joint Authors
Mahmood Zuhdi, Ahmad Syadi
Krackhardt, Florian
Waliszewski, Matthias W.
Ismail, Muhammad Dzafir
Boxberger, Michael
Wan Ahmad, Wan Azman
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes.
The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization.
We investigated the efficacy and safety of polymer-free ultrathin strut sirolimus-probucol coated drug-eluting stents (PF-SES) for CTO lesions.
Methods.
Patients with CTO lesions treated with PF-SES were identified from the prospective multicenter international ISAR 2000 registry.
The primary endpoint was clinically driven target lesion revascularization (TLR) at 9 months.
Secondary endpoints were 9-month major adverse cardiac events (death, myocardial infarction, or TLR) (MACE) and the occurrence of stent thrombosis.
Results.
A total of 111 patients with CTO lesions (n=127) were available for analysis.
The 9-month clinical follow-up rate was 91%.
The mean reference vessel diameter and lesion length were 2.76 mm ± 0.40 and 26.8 mm ± 13.1, respectively.
The overall DAPT duration was 9.7 ± 2.8 months.
Only one (1%) in-hospital MI was reported.
The TLR and MACE rates at 9 months were 2% (2/101) and 5.9% (6/101), respectively.
The 9-month accumulated rates of definite or probable stent thrombosis was 0% (0/101).
Conclusion.
Revascularizations for CTO with PF-SES are associated with low rates of TLR and MACE at 9 months with no stent thrombosis.
These initial findings need to be compared with results of other new generation DES of larger studies.
American Psychological Association (APA)
Mahmood Zuhdi, Ahmad Syadi& Krackhardt, Florian& Waliszewski, Matthias W.& Ismail, Muhammad Dzafir& Boxberger, Michael& Wan Ahmad, Wan Azman. 2018. Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152100
Modern Language Association (MLA)
Mahmood Zuhdi, Ahmad Syadi…[et al.]. Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry. Cardiology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1152100
American Medical Association (AMA)
Mahmood Zuhdi, Ahmad Syadi& Krackhardt, Florian& Waliszewski, Matthias W.& Ismail, Muhammad Dzafir& Boxberger, Michael& Wan Ahmad, Wan Azman. Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152100