Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction
Joint Authors
Alizade, Elnur
Pala, Selcuk
Sari, Munevver
Kahveci, Gokhan
Arslantas, Ugur
Uslu, Abdulkadir
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of the study was to determine an association between the plasma YKL-40 level and echocardiographic left ventricle systolic and diastolic function parameters in patients with acute myocardial infarction.
Subjects and Methods.
The study included 46 patients with acute myocardial infarction.
Serum brain natriuretic protein (BNP) and YKL-40 levels were analyzed on admission and after one month.
Left ventricle systolic and diastolic functions and Tei index were computed by transthoracic echocardiography.
Results.
Plasma YKL-40 was significantly higher in patients with acute myocardial infarction (AMI) (101.7 μg/L versus 34 μg/L, resp., p<0.001) and remained higher than in healthy subjects after one month.
The levels of YKL-40 on admission were correlated with log BNP on admission (r=0.41,p=0.004), Tei index (r=0.44,p=0.002), left atrium volume index (r=0.32,p=0.02), and mitral septal annular E/e′ (r=0.44,p=0.003).
Death was more frequently observed in patients with plasma YKL-40 above the median value than in those with plasma YKL-40 below the median value (p=0.001; OR = 13.6 (2.5–72.3)).
Conclusion.
YKL-40 elevations in patients with AMI remain at least one month and are associated with serum BNP elevations, diastolic dysfunction, and long-term increased overall mortality.
It has prognostic importance in patients with AMI.
American Psychological Association (APA)
Pala, Selcuk& Sari, Munevver& Kahveci, Gokhan& Alizade, Elnur& Arslantas, Ugur& Uslu, Abdulkadir. 2018. Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152114
Modern Language Association (MLA)
Pala, Selcuk…[et al.]. Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction. Cardiology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1152114
American Medical Association (AMA)
Pala, Selcuk& Sari, Munevver& Kahveci, Gokhan& Alizade, Elnur& Arslantas, Ugur& Uslu, Abdulkadir. Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1152114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152114