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ThiolDisulfide Balance in Patients with Familial Hypercholesterolemia
Joint Authors
Koca, Cemile
Alısık, Murat
Şimşek, Özgür
Çarlıoğlu, Ayşe
Edem, Efe
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage.
Methods.
In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects.
Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf tubes, and preserved at −80°C.
Results.
This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index).
This means that in such patients, the thiol/disulfide balance changes in favour of disulfide.
Conclusions.
In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide.
American Psychological Association (APA)
Şimşek, Özgür& Çarlıoğlu, Ayşe& Koca, Cemile& Edem, Efe& Alısık, Murat. 2018. ThiolDisulfide Balance in Patients with Familial Hypercholesterolemia. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1152120
Modern Language Association (MLA)
Şimşek, Özgür…[et al.]. ThiolDisulfide Balance in Patients with Familial Hypercholesterolemia. Cardiology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1152120
American Medical Association (AMA)
Şimşek, Özgür& Çarlıoğlu, Ayşe& Koca, Cemile& Edem, Efe& Alısık, Murat. ThiolDisulfide Balance in Patients with Familial Hypercholesterolemia. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1152120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152120