Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer
Joint Authors
Jiang, Tao
Yang, Chun
Ma, Liyuan
Wu, Zehua
Ye, Ling
Ma, Xiaoqiang
Li, Hai
Fan, Junwei
Yang, Yinxue
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Deregulation of G protein-coupled receptor kinase 3 (GRK3), which belongs to a subfamily of kinases called GRKs, acts as a promoter mechanism in some cancer types.
Our study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa (P<0.01).
Based on immunohistochemistry staining of TMAs, GRK3 was dramatically stained positive in primary colon cancer (130/180, 72.22%), whereas it was detected minimally or negative in paired normal mucosa specimens (50/180, 27.78%).
Overexpression of GRK3 was closely correlated with AJCC stage (P=0.001), depth of tumor invasion (P<0.001), lymph node involvement (P=0.004), distant metastasis (P=0.016), and histologic differentiation (P=0.004).
Overexpression of GRK3 is an independent prognostic indicator that correlates with poor survival in colon cancer patients.
Consistent with this, downregulation of GRK3 exhibited decreased cell growth index, reduction in colony formation ability, elevated cell apoptosis rate, and impaired colon tumorigenicity in a xenograft model.
Hence, a specific overexpression of GRK3 was observed in colon cancer, GRK3 potentially contributing to progression by mediating cancer cell proliferation and functions as a poor prognostic indicator in colon cancer and potentially represent a novel therapeutic target for the disease.
American Psychological Association (APA)
Jiang, Tao& Yang, Chun& Ma, Liyuan& Wu, Zehua& Ye, Ling& Ma, Xiaoqiang…[et al.]. 2017. Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152125
Modern Language Association (MLA)
Jiang, Tao…[et al.]. Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152125
American Medical Association (AMA)
Jiang, Tao& Yang, Chun& Ma, Liyuan& Wu, Zehua& Ye, Ling& Ma, Xiaoqiang…[et al.]. Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152125