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MIF mRNA Expression and Soluble Levels in Acute Coronary Syndrome
Joint Authors
Padilla-Gutiérrez, Jorge Ramón
Flores-Salinas, Hector Enrique
Valle, Yeminia
García-González, Ilian Janet
Muñoz-Valle, Jose F.
Valdés-Alvarado, Emmanuel
Sandoval-Pinto, Elena
Valdez-Haro, Angélica
Pérez-Ibarra, Jorge Manuel
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acute coronary syndrome (ACS) describes any condition characterized by myocardial ischaemia and reduction in blood flow.
The physiopathological process of ACS is the atherosclerosis where MIF operates as a major regulator of inflammation.
The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG).
All samples were run using the conditions indicated in TaqMan Gene Expression Assay protocol.
Determination of MIF serum levels were performed by enzyme-linked immunosorbent assay and MIF ELISA Kit.
ST-segment elevation myocardial infraction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) showed 0.8 and 0.88, respectively, less expression of MIF mRNA with regard to CG.
UA and STEMI presented more expression than NSTEMI 5.23 and 0.68, respectively.
Otherwise, ACS patients showed significant higher MIF serum levels (p=0.02) compared with CG.
Furthermore, the highest soluble levels of MIF were presented by STEMI (11.21 ng/dL), followed by UA (10.34 ng/dL) and finally NSTEMI patients (8.75 ng/dL); however, the differences were not significant.
These novel observations further establish the process of MIF release after cardiovascular events and could support the idea of MIF as a new cardiac biomarker in ACS.
American Psychological Association (APA)
Valdés-Alvarado, Emmanuel& Valle, Yeminia& Muñoz-Valle, Jose F.& García-González, Ilian Janet& Valdez-Haro, Angélica& Flores-Salinas, Hector Enrique…[et al.]. 2018. MIF mRNA Expression and Soluble Levels in Acute Coronary Syndrome. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1152131
Modern Language Association (MLA)
Valdés-Alvarado, Emmanuel…[et al.]. MIF mRNA Expression and Soluble Levels in Acute Coronary Syndrome. Cardiology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1152131
American Medical Association (AMA)
Valdés-Alvarado, Emmanuel& Valle, Yeminia& Muñoz-Valle, Jose F.& García-González, Ilian Janet& Valdez-Haro, Angélica& Flores-Salinas, Hector Enrique…[et al.]. MIF mRNA Expression and Soluble Levels in Acute Coronary Syndrome. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1152131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152131