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Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?
Joint Authors
Luo, Ruijie
Lin, Ziqi
Xia, Qing
Shi, Na
Deng, Lihui
Chen, Weiwei
Zhang, Xiaoxin
Jin, Tao
Ma, Yun
Du, Chen
Jiang, Kun
Guo, Jia
Yang, Xiaonan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI).
Methods.
Rats were administrated with retrograde cholangiopancreatography injection of 0.5% or 3.5% sodium taurocholate to induce AP with mild or severe LI and were sacrificed at 6, 12, and 24 h.
Rats from the control group received a laparotomy only.
Plasma from a prospective cohort of AP patients was collected.
The levels of miR-127 in the tissues and plasma were detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
Results.
The upregulation of miR-127 in the lungs of rats was detected in the groups of AP with severe LI at 6 h and 24 h, whereas it was scarcely detectable in plasma.
In the pilot study that included 18 AP patients and 5 healthy volunteers, the plasma miR-127 level was significantly downregulated in AP patients with respiratory failure compared with the healthy volunteers (P=0.014) and those without respiratory failure (P=0.043).
Conclusion.
miR-127 might serve as a potential marker for the identification of AP with LI.
American Psychological Association (APA)
Shi, Na& Deng, Lihui& Chen, Weiwei& Zhang, Xiaoxin& Luo, Ruijie& Jin, Tao…[et al.]. 2017. Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152140
Modern Language Association (MLA)
Shi, Na…[et al.]. Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152140
American Medical Association (AMA)
Shi, Na& Deng, Lihui& Chen, Weiwei& Zhang, Xiaoxin& Luo, Ruijie& Jin, Tao…[et al.]. Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury?. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152140