Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues
Author
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mammalian target of rapamycin (mTOR) is a key controller of cell growth and proliferation in normal tissues and solid tumors.
In the present study, an immunohistochemical analysis of the expression pattern of phosphorylated mTOR (p-mTOR) was performed in human normal fetal and adult tissues and various carcinoma tissues.
p-mTOR expression showed tissue and cell type specificity in normal and cancer tissues.
In normal fetal and adult tissues, p-mTOR staining was observed in the intestinal crypt, intrahepatic bile ductule, pancreatic duct, distal nephron of the kidney, umbrella cell of urothelium, mesothelial cell, and choroid plexus.
In cancer tissues, p-mTOR expression was higher in adenocarcinoma than in other types of cancers, in metastatic cancer than in primary cancer, and in the forefront of the infiltrating cancer cells.
These results suggest that p-mTOR is implicated not only in cell proliferation but also in tubular morphogenesis in normal and cancer tissues.
In addition, mTOR activation appears to be associated with cancer cell invasion and migration in solid tumors.
American Psychological Association (APA)
Lee, Hojung. 2017. Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152169
Modern Language Association (MLA)
Lee, Hojung. Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152169
American Medical Association (AMA)
Lee, Hojung. Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152169