Benign Solitary Pulmonary Necrotic Nodules: How Effectively Does Pathological Examination Explain the Cause?
Joint Authors
Ürer, Nur
Gunluoglu, Mehmet Zeki
Unver, Nurcan
Toprak, Sezer
Ortakoylu, Mediha Gonenc
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aims.
We investigated the histopathological features of solitary pulmonary necrotic nodules (NNs) of undetermined cause.
We combined our findings with those obtained using other methods to determine how well the etiological factors were explained.
Methods.
We screened patients who underwent surgery to treat solitary pulmonary granulomatous and nongranulomatous NNs of undetermined cause.
The NN sizes and features of both the NNs and adjacent parenchyma were evaluated.
Histochemical analyses included Ehrlich–Ziehl–Neelsen (EZN), Grocott, and Gram staining.
Polymerase chain reaction (PCR) was used to detect tuberculous and nontuberculous mycobacteria, panfungal DNA, Nocardia, Francisella tularensis types A and B, and actinomycetes.
Results.
The NNs were granulomatous in 78.9% and nongranulomatous in 21% of the 114 patients included.
EZN staining or PCR was positive for Mycobacterium in 53.5% of all NNs: 62.2% of granulomatous and 20.8% of nongranulomatous NNs.
We found a weak but significant correlation between granulomatous NNs and Bacillus positivity and a significant correlation between granulomas surrounding the NNs and the presence of multiple necroses.
The NN etiology was determined via histopathological, histochemical, and PCR analyses in 57% of patients but remained undetermined in 42.9%.
Conclusion.
The causes of both granulomatous and nongranulomatous NNs can be determined by pathological examination.
Granulomatous necrosis and granulomas in the adjacent parenchyma are important for differential diagnosis.
When both features are present, they strongly support a diagnosis of tuberculosis, even in the absence of bacilli.
American Psychological Association (APA)
Ürer, Nur& Gunluoglu, Mehmet Zeki& Unver, Nurcan& Toprak, Sezer& Ortakoylu, Mediha Gonenc. 2020. Benign Solitary Pulmonary Necrotic Nodules: How Effectively Does Pathological Examination Explain the Cause?. Canadian Respiratory Journal،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1152197
Modern Language Association (MLA)
Ürer, Nur…[et al.]. Benign Solitary Pulmonary Necrotic Nodules: How Effectively Does Pathological Examination Explain the Cause?. Canadian Respiratory Journal No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1152197
American Medical Association (AMA)
Ürer, Nur& Gunluoglu, Mehmet Zeki& Unver, Nurcan& Toprak, Sezer& Ortakoylu, Mediha Gonenc. Benign Solitary Pulmonary Necrotic Nodules: How Effectively Does Pathological Examination Explain the Cause?. Canadian Respiratory Journal. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1152197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152197