A Retrospective Analysis of Crayfish-Related Rhabdomyolysis (Haff Disease)‎

Abstract EN

Objective.

To investigate the epidemiologic and etiologic factors, clinical features, therapeutic regimen, and prognosis of crayfish-related rhabdomyolysis (Haff disease).

Methods.

Retrospectively analyzed the clinical data of 29 patients with crayfish-related rhabdomyolysis (Haff disease) from July to August 2016, summarized the clinical characteristics, and evaluated the prognosis.

Results.

Clinical data of a total of 29 cases of Haff disease were retrospectively analyzed.

The disease onset occurred after consumption of cooked crayfish with the incubation period ranging from 1 h to 48 h.

There were no gender differences and significantly elevated CK in the duration with peak value of 41575.0U/L; the median value was 2445.0U/L (range: from 1187.0 U/L to 4722.0 U/L) and there was coincident elevated CK-MB.

There was also no hepatorenal damage and transient urinalysis was abnormal.

The most common presenting symptoms were myalgia (100%), weakness and numbness (51.7%), chest tightness and chest pain (41.4%), back pain (41.4%), and extremities pain (37.9%).

All the patients recovered and no patients died.

Conclusions.

Crayfish-related rhabdomyolysis (Haff disease) is a kind of a case or cluster of patients present with severe myalgia or weakness of unknown etiology and mechanism disease; however, the clinical signs and symptoms are relatively mild with favorable outcome.