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Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients
Joint Authors
Wang, Xudong
Liu, Can
Zhou, Nan
Li, Jieying
Kong, Jun
Guan, Xi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Eg5 (kinesin spindle protein) plays an essential role in mitosis.
Inhibition of Eg5 function results in cell cycle arrest at mitosis, which leads to cell death.
To date, Eg5 expression and its prognostic significance have not been studied in hepatocellular carcinoma (HCC).
In this study, 26 freshly frozen HCC tissue samples and matched peritumoral tissue samples were evaluated with a one-step qPCR test and immunohistochemical (IHC) analysis was conducted on 156 HCC samples to investigate the relationships among Eg5 expression, clinicopathological factors, and prognosis.
Eg5 mRNA and protein expression levels were significantly higher in HCC tissues relative to matched noncancerous tissues (p<0.05).
High Eg5 protein expression was significantly related to liver cirrhosis (p=0.038) and TNM stage (p=0.008).
Kaplan-Meier survival and Cox regression analyses revealed that Eg5 overexpression (p=0.001), liver cirrhosis (p=0.009), and TNM stage (p=0.025) were independent prognostic factors for overall survival.
These findings indicate that Eg5 expression can be used as a biomarker of poor prognosis and as a novel therapeutic target for HCC.
American Psychological Association (APA)
Liu, Can& Zhou, Nan& Li, Jieying& Kong, Jun& Guan, Xi& Wang, Xudong. 2017. Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152225
Modern Language Association (MLA)
Liu, Can…[et al.]. Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152225
American Medical Association (AMA)
Liu, Can& Zhou, Nan& Li, Jieying& Kong, Jun& Guan, Xi& Wang, Xudong. Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152225