Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population
Joint Authors
Li, Jin
Hu, Jing
Sun, Rong
Zhao, Yongpan
Liu, Heping
Li, Jian
Shi, Lei
Zhao, Shujin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide.
Secondary hypertension can result from mutations of cullin-3 (CUL3); however, whether polymorphisms of CUL3 are associated with essential hypertension (EH) has not been reported.
Here, we investigated the association between CUL3 SNPs rs17479770 and rs3738952 and EH in the Chinese Han population.
Methods.
This case-control study investigated 520 representatives, including 259 patients with EH and 261 normotensive controls matched for age, gender, BMI, TG, TC, and HbA1c for the distribution of functional rs17479770 and rs3738952 within the CUL3 gene by using PCR and RFLP.
Results.
Our results showed that there was no significant difference in allele and genotype distribution of rs3738952 and haplotype distribution of rs17479770 and rs3738952 between the EH group and normotensive group, whereas the rs17479770 TT genotype in male and the full data set were significantly associated with the decreased risk of EH (P=0.050, P=0.042), and rs17479770 allele T in male was shown to have the correlation tendency of the decreased risk of EH (P=0.064).
Conclusion.
Our data suggest that the CUL3 rs17479770 variant could be a protective factor in the pathogenesis of EH.
American Psychological Association (APA)
Li, Jin& Hu, Jing& Sun, Rong& Zhao, Yongpan& Liu, Heping& Li, Jian…[et al.]. 2017. Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152271
Modern Language Association (MLA)
Li, Jin…[et al.]. Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152271
American Medical Association (AMA)
Li, Jin& Hu, Jing& Sun, Rong& Zhao, Yongpan& Liu, Heping& Li, Jian…[et al.]. Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152271