A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia
Joint Authors
Yu, Yaqin
Shi, Jieping
Yu, Qiong
Rao, Wenwang
Zhou, Na
Zhang, Huiping
Liu, Rui
Zhang, Shangchao
Su, Yingying
Yang, Guang
Ma, Yue
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis.
We sought further to demonstrate that variants in the fibrinogen alpha chain gene (FGA) coded FPA might confer vulnerability to schizophrenia.
1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited.
The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5′UTR, rs2070016 in intron 4, and rs2070022 in the 3′UTR) in FGA and schizophrenia was examined using a case-control study design.
Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011: χ2=1.28, P=0.528; rs2070016: χ2=4.11, P=0.128; rs2070022: χ2=1.23, P=0.541).
There were also no significant differences in SNP allelic frequencies between cases and controls (all P>0.05).
Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (global χ2=9.27, P=0.159).
Our study did not show a significant association of FGA SNPs with schizophrenia.
Future studies may need to test more FGA SNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.
American Psychological Association (APA)
Rao, Wenwang& Zhou, Na& Zhang, Huiping& Liu, Rui& Zhang, Shangchao& Su, Yingying…[et al.]. 2017. A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152276
Modern Language Association (MLA)
Rao, Wenwang…[et al.]. A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152276
American Medical Association (AMA)
Rao, Wenwang& Zhou, Na& Zhang, Huiping& Liu, Rui& Zhang, Shangchao& Su, Yingying…[et al.]. A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152276