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A Novel Panel of Serum Biomarkers for MPM Diagnosis
Joint Authors
Comar, Manola
Foddis, Rudy
Bonotti, A.
Landi, S.
Melaiu, O.
De Santi, C.
Giusti, L.
Donadio, E.
Ciregia, F.
Mazzoni, M. R.
Lucacchini, A.
Bovenzi, M.
Pantani, E.
Pistelli, A.
Cristaudo, A.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Exposure to asbestos is the main cause of malignant pleural mesothelioma (MPM), a highly aggressive cancer of the pleura.
Since the only tools for early detection are based on radiological tests, some authors focused on serum markers (i.e., mesothelin).
The aim of this study was the evaluation of new serum biomarkers to be used individually or in combination, in order to improve the outcome of patients whose disease would be diagnosed at an earlier stage.
Serum and plasma were available from 43 subjects previously exposed to asbestos and 27 MPM patients, all being epithelioid type.
All the new markers found differentially expressed in MPM and healthy subjects, by proteomic and genomic approaches, have been validated in the serum by the use of specific ELISA.
The combined approach, using tools of genomics and proteomics, is found to be highly innovative for this type of disease and led to the identification of new serum markers in the diagnosis of MPM.
These results, if confirmed in a larger series, may have a strong impact in this area, because early detection of this cancer in people at high risk could significantly improve the course of the disease and the clinical approach to an individualized therapy.
American Psychological Association (APA)
Bonotti, A.& Foddis, Rudy& Landi, S.& Melaiu, O.& De Santi, C.& Giusti, L.…[et al.]. 2017. A Novel Panel of Serum Biomarkers for MPM Diagnosis. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152294
Modern Language Association (MLA)
Bonotti, A.…[et al.]. A Novel Panel of Serum Biomarkers for MPM Diagnosis. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152294
American Medical Association (AMA)
Bonotti, A.& Foddis, Rudy& Landi, S.& Melaiu, O.& De Santi, C.& Giusti, L.…[et al.]. A Novel Panel of Serum Biomarkers for MPM Diagnosis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152294