The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients
Joint Authors
Chen, Changguo
Chen, Lei
Chen, Changwei
Chen, Qiuyuan
Zhao, Qiangyuan
Dong, Youyou
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tuberculosis is caused by mycobacterium, a potentially fatal infectious bacterium.
In recent years, TB cases increased in the whole world.
WHO statistics data shows that the world’s annual tuberculosis incidence was 8~10 million with about 3 million deaths.
Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms.
Here, we report the distribution frequency of IFNGR1 gene polymorphisms in 103 cases of IGA-negative patients and 100 cases of IGA-positive patients from China by sequencing the IFNGR1 proximal ~750 bp promoter region.
We found a total of 5 types of site mutations: -611 (G/A), -56 (T/C), -255 (C/T), -359 (T/C), and -72 (C/T).
The two main types of gene polymorphisms among the IGA-negative and IGA-positive groups were -611 (G/A), with mutation rates of 88.3% and 78.4%, respectively, and -56 (T/C), with mutation rates of 84.5% and 83.8%, respectively, which had no statistical significance, and there was no correlation with the incidence of tuberculosis.
American Psychological Association (APA)
Chen, Changguo& Chen, Lei& Chen, Changwei& Chen, Qiuyuan& Zhao, Qiangyuan& Dong, Youyou. 2017. The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152307
Modern Language Association (MLA)
Chen, Changguo…[et al.]. The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152307
American Medical Association (AMA)
Chen, Changguo& Chen, Lei& Chen, Changwei& Chen, Qiuyuan& Zhao, Qiangyuan& Dong, Youyou. The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152307