Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country
Joint Authors
Ghouse, Ayaz
Waheed, Shahan
Bryan, Nathan S.
Mian, Asad I.
Kamal, Ayeesha Kamran
Source
Emergency Medicine International
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Acute stroke incites an inflammatory reaction in the brain’s microvasculature, activating formation of nitric oxide oxidative metabolites, nitrate and nitrite (NOx, collectively), measurable in plasma.
Our objectives were to investigate plasma NOx in patients with acute stroke presenting to the Emergency Department (ED) and to determine if it could (i) differentiate between ischemic and hemorrhagic stroke; (ii) predict clinical outcomes.
Methods.
A cross-sectional study was conducted in the ED of Aga Khan University Hospital, from January 1 to December 31, 2016.
Participants were enrolled if they had clinical acute stroke with confirmatory brain imaging to differentiate between ischemia and hemorrhage.
Clinical demographic information, ancillary blood, and diagnostic specimens were collected as per standard of care since the center follows stroke algorithmic guidelines.
Plasma NOx analysis was performed using high performance liquid chromatography.
Clinical outcomes were assessed using Barthel Index and Modified Rankin Score.
Data was analyzed using SPSS 19 and expressed in medians with interquartile ranges.
Nonparametric tests were applied for comparing among groups.
Pearson’s correlation was used to determine associations with aforementioned stroke severity and disability scales.
Results.
Seventy-five patients were enrolled, with median age of 57 years (IQR 47-66 years), 53 (71%) were males, and 46 (61%) had ischemic stroke.
Overall, median NOx was 20.8 μM (IQR 13.4-35.3); there was no statistically significant difference between NOx in ischemic versus hemorrhagic stroke (21.2 μM vs.
17.9 μM; p=0.2).
However, there was a significant positive correlation between NOx levels and aforementioned acute stroke scales [r(73)=0.417, p=0.0001], for both.
Conclusion.
Although plasma NOx could not differentiate between ischemia and hemorrhage, higher levels of the biomarker did show associations with poststroke disability scales.
Further study with more patients in a multicenter trial is warranted to establish the real biomarker potential of plasma NOx in acute stroke.
American Psychological Association (APA)
Waheed, Shahan& Ghouse, Ayaz& Kamal, Ayeesha Kamran& Bryan, Nathan S.& Mian, Asad I.. 2019. Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country. Emergency Medicine International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1152329
Modern Language Association (MLA)
Waheed, Shahan…[et al.]. Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country. Emergency Medicine International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1152329
American Medical Association (AMA)
Waheed, Shahan& Ghouse, Ayaz& Kamal, Ayeesha Kamran& Bryan, Nathan S.& Mian, Asad I.. Association of Plasma Levels of Nitric Oxide Oxidative Metabolites with Acute Stroke in Patients Presenting to the Emergency Department of a Low-Middle Income Country. Emergency Medicine International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1152329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152329