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Expression and Clinical Significance of ILF2 in Gastric Cancer
Joint Authors
Yu, Dong-Feng
Yin, Zi-huan
Jiang, Xing-wang
Shi, Wu-bing
Gui, Qian-le
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study is to investigate the expression levels and clinical significance of ILF2 in gastric cancer.
The mRNA and protein expression levels of ILF2 were, respectively, examined by quantitative real-time PCR (qRT-PCR) and Western blot from 21 paired fresh frozen GC tissues and corresponding normal gastric tissues.
In order to analyze the expression pattern of ILF2 in GC, 60 paired paraffin-embedded GC slides and corresponding normal gastric slides were detected by immunohistochemistry (IHC) assay.
The correlation between ILF2 protein expression levels and clinicopathological parameters, overall survival (OS), disease-free survival (DFS), and clinical prognosis were analyzed by statistical methods.
Significantly higher levels of ILF2 were detected in GC tissues compared with normal controls at both mRNA and protein level.
High expression of ILF2 was tightly correlated with depth of invasion, lymph node metastasis, pathological stage, and histological differentiation.
Log-rank test showed that high expression of ILF2 was positively associated with poor clinical prognosis.
Multivariate analysis identified that ILF2 was an independent prognostic factor for OS and DFS.
Our findings suggest that ILF2 may be a valuable biomarker and a novel potential prognosis predictor for GC patients.
American Psychological Association (APA)
Yin, Zi-huan& Jiang, Xing-wang& Shi, Wu-bing& Gui, Qian-le& Yu, Dong-Feng. 2017. Expression and Clinical Significance of ILF2 in Gastric Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152334
Modern Language Association (MLA)
Yin, Zi-huan…[et al.]. Expression and Clinical Significance of ILF2 in Gastric Cancer. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152334
American Medical Association (AMA)
Yin, Zi-huan& Jiang, Xing-wang& Shi, Wu-bing& Gui, Qian-le& Yu, Dong-Feng. Expression and Clinical Significance of ILF2 in Gastric Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152334