A Rational Adoption of the High Sensitive Assay for Cardiac Troponin I in Diagnostic Routine
Joint Authors
Croce, Antonio
Brunati, Pietro
Colzani, Carlo
Terramocci, Riccardo
Favero, Stefano
Bordoni, Gabriele
Galli, Claudio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We describe the adoption of high sensitive troponin I (hsTnI) in clinical practice in two hospital settings in Italy.
Samples from 426 consecutive patients (mean age 68.8 ± 17.0) admitted to the Emergency Department with a suspected acute coronary syndrome (ACS) have been tested at admittance and after 3 and 6 hours by contemporary TnI and hsTnI.
Results have been compared to the final clinical diagnosis.
Troponin was detectable in 68.6% by TnI and 89.9% by hsTnI.
Since hsTnI has a lower threshold for females, 38/41 patients with positive values only by hsTnI were women.
The correlation between the assays was very high (r=0.92).
A diagnosis of acute myocardial infarction (AMI) was made in 45 cases (10.5%).
The negative and positive predictive values for a 50% troponin variation at 3 hours were 95.8% and 66.7% for hsTnI and 95.0% and 52.6% for TnI and at 6 hours 90.3% and 100% for hsTnI and 88.9% and 78.9% for TnI, respectively.
Receiver operating characteristic (ROC) curve analysis demonstrated a greater efficiency by hsTnI at 3 hours versus 6 hours (AUC = 0.91 versus 0.72).
The main benefits of hsTnI are the adoption of gender-specific 99th percentile and the shortening of time to decision.
American Psychological Association (APA)
Croce, Antonio& Brunati, Pietro& Colzani, Carlo& Terramocci, Riccardo& Favero, Stefano& Bordoni, Gabriele…[et al.]. 2017. A Rational Adoption of the High Sensitive Assay for Cardiac Troponin I in Diagnostic Routine. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152337
Modern Language Association (MLA)
Croce, Antonio…[et al.]. A Rational Adoption of the High Sensitive Assay for Cardiac Troponin I in Diagnostic Routine. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152337
American Medical Association (AMA)
Croce, Antonio& Brunati, Pietro& Colzani, Carlo& Terramocci, Riccardo& Favero, Stefano& Bordoni, Gabriele…[et al.]. A Rational Adoption of the High Sensitive Assay for Cardiac Troponin I in Diagnostic Routine. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152337