Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population
Joint Authors
Guo, ChaoFeng
Zhou, Ying
Tan, Chun-yan
Mo, Zhi-jiang
Gao, Qi-le
He, Dan
Li, Jiong
Huang, Rong-fu
Li, Yan-bing
Guo, Qiang
Wang, Long-jie
Yang, Guan-teng
Zhang, Hong-qi
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the association of single-nucleotide polymorphisms (SNPs) in SP110 gene and TNF-α gene among pulmonary TB (PTB) and spinal TB (STB) patients.
Methods.
In a total of 190 PTB patients, 183 STB patients were enrolled as the case group and 362 healthy individuals at the same geographical region as the control group.
The SP110 SNPs (rs722555 and rs1135791) and the promoter -308G>A (rs1800629) and -238G>A (rs361525) polymorphisms in TNF-α were genotyped.
Results.
TNF-α -238G>A polymorphism was involved in susceptibility to STB, but not to PTB.
The TNF-α -238 A allele was a protective factor against STB (A versus G: OR [95% CI] = 0.331 [0.113–0.972], P=0.044).
Furthermore, the presence of the -238 A allele was considered a trend to decrease the risk of STB (AG versus GG: P=0.062, OR [95% CI] = 0.352 [0.118–1.053]; AA + AG versus GG: P=0.050, OR [95CI%] = 0.335 [0.113–0.999]).
However, SP110 SNPs (rs722555 and rs1135791) and TNF-α -308G>A (rs1800629) showed no association with PTB and STB in all genetic models.
Conclusion.
The TNF-α -238 A allele appeared a protective effect against STB, whereas the SP110 SNPs (rs722555 and rs1135791) and TNF-α -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.
American Psychological Association (APA)
Zhou, Ying& Tan, Chun-yan& Mo, Zhi-jiang& Gao, Qi-le& He, Dan& Li, Jiong…[et al.]. 2017. Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152343
Modern Language Association (MLA)
Zhou, Ying…[et al.]. Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152343
American Medical Association (AMA)
Zhou, Ying& Tan, Chun-yan& Mo, Zhi-jiang& Gao, Qi-le& He, Dan& Li, Jiong…[et al.]. Polymorphisms in the SP110 and TNF-α Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152343