Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Joint Authors

Jiang, Jing
Cao, Donghui
You, Lili
Jia, Zhifang
Cao, Xueyuan
Wu, Xing
Wen, Simin
Pan, Yuchen
Wu, Yanhua
Wang, Chuan

Source

Disease Markers

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-02-19

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

Gastric cancer (GC) is one of the most prominent global cancer-related health threats.

Genes play a key role in the precise mechanisms of gastric cancer.

SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC.

Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility.

Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis.

The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93, P = 0.009 ) compared to the T/T genotype.

Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95, P = 0.016 ).

This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

American Psychological Association (APA)

Wu, Yanhua& Jia, Zhifang& Cao, Donghui& Wang, Chuan& Wu, Xing& You, Lili…[et al.]. 2017. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152349

Modern Language Association (MLA)

Wu, Yanhua…[et al.]. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152349

American Medical Association (AMA)

Wu, Yanhua& Jia, Zhifang& Cao, Donghui& Wang, Chuan& Wu, Xing& You, Lili…[et al.]. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152349

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1152349