Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis
Joint Authors
Jiang, Jing
Cao, Donghui
You, Lili
Jia, Zhifang
Cao, Xueyuan
Wu, Xing
Wen, Simin
Pan, Yuchen
Wu, Yanhua
Wang, Chuan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gastric cancer (GC) is one of the most prominent global cancer-related health threats.
Genes play a key role in the precise mechanisms of gastric cancer.
SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC.
Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility.
Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis.
The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93, P = 0.009 ) compared to the T/T genotype.
Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95, P = 0.016 ).
This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.
American Psychological Association (APA)
Wu, Yanhua& Jia, Zhifang& Cao, Donghui& Wang, Chuan& Wu, Xing& You, Lili…[et al.]. 2017. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152349
Modern Language Association (MLA)
Wu, Yanhua…[et al.]. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152349
American Medical Association (AMA)
Wu, Yanhua& Jia, Zhifang& Cao, Donghui& Wang, Chuan& Wu, Xing& You, Lili…[et al.]. Predictive Value of MiR-219-1, MiR-938, MiR-34bc, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152349