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Elevated Concentrations of SERPINE2Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer
Joint Authors
Lawnicka, Hanna
Stępień, Tomasz
Brożyna, Mateusz
Kuzdak, Krzysztof
Motylewska, Ewelina
Komorowski, Jan
Stępień, Henryk
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth.
However, their role in the pathogenesis of thyroid cancer has not been determined.
Materials and Methods.
The aim of this study was to assess serum SERPINE2 and SLPI concentrations in a group of 36 patients with papillary thyroid cancer (PTC) and a group of 19 subjects with multinodular nontoxic goiter (MNG).
The control group (CG) consisted of 20 healthy volunteers.
Blood samples were collected one day before surgery.
Serum SERPINE2 and SLPI concentrations were measured using specific ELISA methods.
Results.
Significantly higher concentrations of SERPINE2 and SLPI were found in patients with PTC as compared with MNG and controls.
Positive correlation was found between SERPINE2 and SLPI concentrations in PTC patients.
The levels of SERPINE2 and SLPI did not differ significantly between MNG and healthy controls.
Conclusions.
Our results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
American Psychological Association (APA)
Stępień, Tomasz& Brożyna, Mateusz& Kuzdak, Krzysztof& Motylewska, Ewelina& Komorowski, Jan& Stępień, Henryk…[et al.]. 2017. Elevated Concentrations of SERPINE2Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152361
Modern Language Association (MLA)
Stępień, Tomasz…[et al.]. Elevated Concentrations of SERPINE2Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. Disease Markers No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1152361
American Medical Association (AMA)
Stępień, Tomasz& Brożyna, Mateusz& Kuzdak, Krzysztof& Motylewska, Ewelina& Komorowski, Jan& Stępień, Henryk…[et al.]. Elevated Concentrations of SERPINE2Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1152361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152361